Roseola infantum and other syndromes associated with acute HHV6 infection.
- 1 December 1990
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 65 (12), 1297-1300
- https://doi.org/10.1136/adc.65.12.1297
Abstract
Eight cases of acute human herpesvirus type 6 (HHV6) infection in infants were diagnosed serologically by the demonstration of IgM anti-HHV6 (8/8) and a significant change in total anti-HHV6 antibody titre (6/8). Four infants were sufficiently ill to require admission to hospital and further investigations: one with encephalitis and three with gross hepatosplenomegaly, two of whom had evidence of simultaneous infection with another herpes-virus. The remaining four infants had an illness compatible with roseola infantum, although this diagnosis had not been made clinically. Sera from two of those infants with rash had been sent for analysis to exclude rubella because the infants' mothers were pregnant. The other two had received antibiotics when febrile, and the subsequent appearance of the roseola rash had raised the possibility of antibiotic allergy. The data suggest that there are clinical syndromes in addition to roseola infantum associated with the presence of IgM anti-HHV6, in which serological screening for evidence of acute HHV6 infection may be useful.This publication has 19 references indexed in Scilit:
- Dual Antibody Rises to Cytomegalovirus and Human Herpesvirus Type 6: Frequency of Occurrence in CMV Infections and Evidence for Genuine Reactivity to Both VirusesThe Journal of Infectious Diseases, 1990
- Serological diagnosis of infection with human herpesvirus type 6.BMJ, 1990
- FATAL PNEUMONIA AFTER GLANDULAR FEVER AND RUBELLAThe Lancet, 1989
- HIGH PREVALENCE OF ANTIBODY TO HUMAN HERPESVIRUS-6 AND SEROCONVERSION ASSOCIATED WITH RASH IN TWO INFANTSThe Lancet, 1988
- IDENTIFICATION OF HUMAN HERPESVIRUS-6 AS A CAUSAL AGENT FOR EXANTHEM SUBITUMThe Lancet, 1988
- ISOLATION OF HUMAN LYMPHOTROPIC HERPESVIRUSES FROM UGANDAThe Lancet, 1987
- Isolation of a New Virus, HBLV, in Patients with Lymphoproliferative DisordersScience, 1986
- Exanthema Subitum and Febrile ConvulsionsActa Paediatrica, 1956
- Pre-eruptive neurological complications of the common contagious diseases—Rubella, rubeola, roseola, and varicellaThe Journal of Pediatrics, 1950
- Exanthem subitum (roseola infantum) complicated by prolonged convulsions and hemiplegiaThe Journal of Pediatrics, 1949