Teratologic evaluation of Δ9‐tetrahydrocannabinol in mice, including a review of the literature

Abstract
Pregnant CD1 mice received 5, 15, 50 and 150 mg/kg/day of Δ9‐THC in sesame oil on days 6–15 of gestation orally by gavage and were killed about one day before expected delivery. Treatment had no effect on maternal weight gain, prenatal mortality rate, fetal weight, and the frequency of gross external, internal, and skeletal abnormalities.