Actionable pathways: interactive discovery of therapeutic targets using signaling pathway models
Open Access
- 2 May 2016
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 44 (W1), W212-W216
- https://doi.org/10.1093/nar/gkw369
Abstract
The discovery of actionable targets is crucial for targeted therapies and is also a constituent part of the drug discovery process. The success of an intervention over a target depends critically on its contribution, within the complex network of gene interactions, to the cellular processes responsible for disease progression or therapeutic response. Here we present PathAct, a web server that predicts the effect that interventions over genes (inhibitions or activations that simulate knock-outs, drug treatments or over-expressions) can have over signal transmission within signaling pathways and, ultimately, over the cell functionalities triggered by them. PathAct implements an advanced graphical interface that provides a unique interactive working environment in which the suitability of potentially actionable genes, that could eventually become drug targets for personalized or individualized therapies, can be easily tested. The PathAct tool can be found at: http://pathact.babelomics.org.Keywords
This publication has 14 references indexed in Scilit:
- Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patientsScience Signaling, 2015
- Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivityScientific Reports, 2015
- Babelomics 5.0: functional interpretation for new generations of genomic dataNucleic Acids Research, 2015
- Personalized genomic analyses for cancer mutation discovery and interpretationScience Translational Medicine, 2015
- Understanding disease mechanisms with models of signaling pathway activitiesBMC Systems Biology, 2014
- Inferring the functional effect of gene expression changes in signaling pathwaysNucleic Acids Research, 2013
- CellBase, a comprehensive collection of RESTful web services for retrieving relevant biological information from heterogeneous sourcesNucleic Acids Research, 2012
- Targeted Cancer Therapies in the Twenty-First Century: Lessons From ImatinibCancer Cell, 2010
- DrugBank: a comprehensive resource for in silico drug discovery and explorationNucleic Acids Research, 2006
- BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and AngiogenesisCancer Research, 2004