Detection of acute myocardial infarction in closed-chest dogs by analysis of regional two-dimensional echocardiographic gray-level distributions.
- 1 January 1983
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 52 (1), 36-44
- https://doi.org/10.1161/01.res.52.1.36
Abstract
We hypothesized that acute myocardial infarction could be detected in standard two-dimensional echocardiograms of closed-chest dogs by evaluating regional echo amplitude distributions using computerized image analysis. We tested this hypothesis by performing standard, 2.4 MHz two-dimensional echoes before and 2 days after circumflex coronary occlusion in seven closed-chest dogs. Control and infarcted regions of interest were studied in digitized stop-frame images. Average gray level was calculated for each region of interest, and the shape of the gray-level distribution was analyzed by calculation of skewness and kurtosis and by qualitative features of shape. Average gray level increased significantly from the pre- to postocclusion images in the infarcted regions (16.7 +/- 4.2 vs. 32.4 +/- 4.4 units, P less than 0.01), but not in the control regions (17.4 +/- 4 vs. 22.3 +/- 5.5., P = NS). Average gray level could not distinguish between infarcted and normal regions within the postocclusion images (36 +/- 5.2 vs. 33.6 +/- 5.8, P = NS). Three independent observers qualitatively evaluated histogram shape and correctly identified 7/7 MI regions (100% sensitivity) and 14/20 normal regions (70% specificity). Quantitatively, infarct regions exhibited a significant decrease in kurtosis from pre- to postocclusion images (7.1 +/- 4.0 vs. 5.2 +/- 2.9, P = NS). Within postocclusion images, infarcted regions displayed a significantly lower kurtosis than did normal regions (0.27 +/- .47 vs. 2.5 +/- 1.0, P less than .01). We conclude that acute myocardial infarction may be detected in closed-chest dogs by analyzing regional echo amplitude data from standard two-dimensional echocardiograms.This publication has 15 references indexed in Scilit:
- Rational gain compensation for attenuation: A step toward quantitative two-dimensional echocardiographyThe American Journal of Cardiology, 1982
- Discrete intramural sonolucency: A new echocardiographic finding in acute myocardial infarctionThe American Journal of Cardiology, 1981
- Cross-sectional echocardiography. I. Analysis of mathematic models for quantifying mass of the left ventricle in dogs.Circulation, 1979
- Ultrasonic Detection of Myocardial Infarction by Amplitude AnalysisRadiology, 1979
- Detection of myocardial scar tissue by M-mode echocardiography.Circulation, 1978
- Detection of myocardial infarction in vitro based on altered attenuation of ultrasound.Circulation Research, 1977
- Systolic thickening and thinning of the septum and posterior wall in patients with coronary artery disease, congestive cardiomyopathy, and atrial septal defect.Circulation, 1977
- Echocardiography in acute myocardial infarctionThe American Journal of Cardiology, 1975
- Echocardiographic findings in experimental myocardial infarction of the posterior left ventricular wallThe American Journal of Cardiology, 1972
- Ultrasonic Detection of Myocardial Infarction in DogPublished by Institute of Electrical and Electronics Engineers (IEEE) ,1972