Endotoxin Shock in the Primate.

Abstract

In 8 anesthetized monkeys intravenous endotoxin from Escherichia coli caused hypotension due to a fall of both cardiac output and total peripheral resistance. Cardiac output was measured by the dye dilution technique. Since infusion of dextran or blood caused the output to rise significantly, it was felt that the output fall was due to a deficient venous return rather than to depressed myocardial function. Central venous pressure stayed at control levels or lower.