Bradykinin activates tyrosine hydroxylase in rat pheochromocytoma PC‐12 cells
- 1 August 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 235 (1-2), 137-140
- https://doi.org/10.1016/0014-5793(88)81249-3
Abstract
Tyrosine hydroxylase is activated in PC-12 cells by bradykinin in a concentration-dependent manner with maximal stimulation occurring at 1 microM. This stimulatory effect occurs within 15 s and is maximal at 5 min. This stimulation is due to an increase in the affinity of tyrosine hydroxylase for its pterin cofactor, and can be blocked by a specific bradykinin receptor antagonist. These data indicate that bradykinin can regulate the activity of tyrosine hydroxylase in PC-12 cells.Keywords
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