Influence of 5-Fluorodeoxyuridine on Growth Characteristics of Rubella Virus.

Abstract

Summary Rubella virus grows to a maximum titer of approximately 10-^5.0 Int.D.₅₀ in LLC-MK₂ cell cultures, with 2:1 input in₅₀ multiplicity. There is always cell-associated virus which accounts for a small portion of the infectious yield. 5-FUDR did not affect in any way the yield of rubella virus as compared to the untreated control. Rubella virus therefore appears to belong to the RNA viruses. The authors are indebted to the Cancer Chemotherapy Service Center for 5-FUDR. The technical assistance of Miss Patricia Gosnell is gratefully acknowledged.