Effect of Oxythiamine on Infection of Mice with the Lansing Strain of Poliomyelitis Virus.

Abstract

Summary Mice from a genetically controlled colony and under controlled environmental conditions were used to examine the effect of oxythiamine, an inhibitory analogue of thiamine, on resistance against the Lansing strain of poliomyelitis. A significant degree of protection was induced in all the groups on the oxythiamine as compared with those on the normal diet. This protection was not quite as marked as in the mice on the low-thiamine diet.