Flow microcalorimetric bioassay of polyene antibiotics: Interaction with growingSaccharomyces cerevisiae

Abstract
Microcalorimetric investigation of the interaction of polyene antibiotics with mid-exponential cells of a growing culture ofSaccharomyces cerevisiae has been used as the basis of a bioassay procedure. The assay is rapid, sensitive and reproducible. The results are compared to classical assays and potency ranking orders.