ADRENO-CORTICAL AND MEDULLARY RESPONSES TO ADENOSINE 3′,5′-MONOPHOSPHATE1
- 31 May 1961
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 68 (6), 908-913
- https://doi.org/10.1210/endo-68-6-908
Abstract
By means of direct arterial perfusion of the isolated intact dog adrenal glands it has been found that adenosine 3′,5′-monophosphate stimulates the continuous secretion of hydrocortisone. During the period of administration of the nuclcotide, the character and magnitude of steroid secretion was comparable to that seen during perfusion of ACTH. Steroidogenesis by rat and guinea pig adrenal slices incubated with 3′,5′-monophosphate was alsostudied, and a species difference in sensitivity of response has been demonstrated. Cathechol amine secretion, studied in the dog adrenal preparation, was unaffected by perfusion of either ACTH or the nucleotide.Keywords
This publication has 1 reference indexed in Scilit:
- Strain differences in urinary hydroxycorticosteroids in guinea pigsAmerican Journal of Physiology-Legacy Content, 1959