Selective DNA attachment of micro- and nanoscale particles to substrates
- 1 February 2002
- journal article
- Published by Springer Nature in Journal of Materials Research
- Vol. 17 (2), 473-478
- https://doi.org/10.1557/jmr.2002.0066
Abstract
Materials formed from micro- and nanoscale particles are of interest because they often exhibit novel optical, electrical, magnetic, chemical, or mechanical properties. In this work, a means of constructing particulate materials using DNA strands to selectively attach micro- and nanoparticles to substrates was demonstrated. Unlike previous schemes, the DNA was anchored covalently to the particles and substrates, rather than through protein intermediaries. Highly reproducible selective attachment of 0.11–0.87 mm-diameter particles was achieved, with selective:nonselective binding ratios >20:1. Calculations showed that at most 350 and 4200 DNA strands were involved in the binding of the small and large particles, respectively. Experiments showed that the DNA was bent at an angle, relative to the surfaces of their solid supports.Keywords
This publication has 18 references indexed in Scilit:
- Invited Review: DNA-mediated artificial nanobiostructures: state of the art and future directionsSuperlattices and Microstructures, 2001
- The BARC biosensor applied to the detection of biological warfare agentsBiosensors and Bioelectronics, 2000
- Optical and Electrical Characterizations of Ultrathin Films Self-Assembled from 11-Aminoundecanoic Acid Capped TiO2Nanoparticles and Polyallylamine HydrochlorideLangmuir, 1999
- High density synthetic oligonucleotide arraysNature Genetics, 1999
- Assembly of Mesoscale Particles over Large Areas and Its Application in Fabricating Tunable Optical FiltersLangmuir, 1998
- DNA SEQUENCING: Massively Parallel GenomicsScience, 1997
- Organization of 'nanocrystal molecules' using DNANature, 1996
- A DNA-based method for rationally assembling nanoparticles into macroscopic materialsNature, 1996
- Direct Mechanical Measurements of the Elasticity of Single DNA Molecules by Using Magnetic BeadsScience, 1992
- Surface energy and the contact of elastic solidsProceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences, 1971