Effect of Intravenous Glibornuride and Tolbutamide on Myocardial Contractility

Abstract

The acute effects of therapeutic doses of i.v. tolbutamide and glibornuride on the systolic time intervals (QS2c [corrected QS2 interval], LVETc [corrected left ventricular ejection time], PEPc [corrected pre-ejection period] and PEP/LVET) were examined in 5 healthy volunteers. Blood glucose was maintained at a constant level throughout the study. No significant changes of these intervals or heart rate and blood pressure were observed. Tolbutamide and glibornuride apparently have no acute positive inotropic action.