Nucleotides in Yeast tRNA Phe Required for the Specific Recognition by Its Cognate Synthetase
- 10 March 1989
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 243 (4896), 1363-1366
- https://doi.org/10.1126/science.2646717
Abstract
An analysis of the aminoacylation kinetics of unmodified yeast tRNAPhe mutants revealed that five single-stranded nucleotides are important for its recognition by yeast phenylalanyl-tRNA synthetase, provided they were positioned correctly in a properly folded tRNA structure. When four other tRNAs were changed to have these five nucleotides, they became near-normal substrates for the enzyme.This publication has 24 references indexed in Scilit:
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