Hypotensive and bradycardic effects of centrally administered vasopressin in stroke-prone spontaneously hypertensive rats.
- 1 September 1987
- journal article
- research article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 10 (3), 346-349
- https://doi.org/10.1161/01.hyp.10.3.346
Abstract
The cardiovascular effects of centrally administered arginine vasopressin were studied in stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats. Arginine vasopressin was infused intracerebroventricularly into conscious rats at a rate of 2 pg/kg/min (4.6 microliter/hr) for 21 hours, and blood pressure and heart rate were monitored. Arginine vasopressin caused transient hypertension and tachycardia in Wistar-Kyoto rats, whereas it induced delayed hypotension and bradycardia in stroke-prone spontaneously hypertensive rats. The effects on the latter lasted for 24 to 72 hours after cessation of the infusion. Intravenous administration of arginine vasopressin at a rate of 2 pg/kg/min did not cause any change in blood pressure and heart rate in these rats. These results suggest that arginine vasopressin acts centrally to depress cardiovascular activities, at least in stroke-prone spontaneously hypertensive rats.This publication has 20 references indexed in Scilit:
- Vasopressin in Circulatory Control and HypertensionJournal Of Hypertension, 1985
- Factors involved in the inactivation of vasopressin after intracerebroventricular injection in miceLife Sciences, 1984
- Vasopressin and oxytocin in the mammalian brain and spinal cordTrends in Neurosciences, 1983
- Central cardiovascular effects of mammalian neurohypophyseal peptides in conscious ratsPeptides, 1983
- Changes in paraventricular vasopressin and oxytocin during the development of spontaneous hypertension.Hypertension, 1983
- Attenuation by arginine- and desglycinamide-lysine-vasopressin of a centrally evoked pressor responseJournal of the Autonomic Nervous System, 1982
- Blood pressure and heart rate responses to microinjection of vasopressin into the nucleus tractus solitarius region of the ratNeuropharmacology, 1982
- Evidence for a direct projection from oxytocin and vasopressin neurons in the hypothalamic paraventricular nucleus to the medulla oblongata: Immunohistochemical visualization of both the horseradish peroxidase transported and the peptide produced by the same neuronsNeuroscience Letters, 1981
- Is cerebrospinal fluid the major avenue for the removal of 5-hydroxyindoleacetic acid from the brain?Neuropharmacology, 1973
- Pressor–Depressor Blood Pressure Responses in the Cat after Intraventricular Injection of DrugsNature, 1962