Neuroleptics are a mainstay in the therapy of delusional parasitosis. We describe a strategy to motivate patients to accept this kind of medicament despite the fact that they usually reject to use psychotropic drugs. We had labeled this motivational strategy ‘hyposensitization’ because we use an injectable depot neuroleptic. The symptoms of the patient are explained as an extreme hypersensitivity of the most peripheral skin nerves. Consequently, this ‘hypersensitivity’ requires a ‘hyposensitization’ akin that in an immediate hypersensitivity reaction (type-I allergy), in their case by a neuroleptic drug, however. Recently, we have used this strategy successfully in a couple with shared delusional parasitosis and in a single patient.