The second pX product p27x‐III of HTLV‐1 is required for gag gene expression
- 15 December 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 209 (2), 187-190
- https://doi.org/10.1016/0014-5793(86)81108-5
Abstract
The human T-cell leukemia virus type-1 (HTLV-1) contains a unique pX region, which encodes the gene products p40 chi, p27 chi-III and p21 chi-III. p40 chi is required for transcriptional trans-activation, whereas p27 chi-III and p21 chi-III have no such function. Transfection of pX expression plasmids containing different combinations for the three gene products into cells integrated with HTLV-1 proviruses defective in pX expression revealed that both p40 chi and p27 chi-III are required for expression of the gag protein and accumulation of gag mRNA. These observations suggest that the pX product p40 chi activates transcription and p27 chi-III controls the level of gag mRNA by post-transcriptional modulation.Keywords
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