THE RELATION BETWEEN THE PHOSPHATE CHANGES IN BLOOD AND MUSCLE, FOLLOWING DEXTROSE, INSULIN AND EPINEPHRIN ADMINISTRATION

Abstract

Observations on the action of dextrose, insulin and epinephrin respectively on the blood and muscle phosphates of normal, depancreatized and adrenalectomized dogs, indicate that the phosphate changes in blood and muscle are not directly related to each other. The fall in blood inorganic phosphate is due to insulin. It is not reflected in a change in the total phosphate content of the blood, and is probably due to an esterification of the inorganic phosphate outside the muscle. The rise in the hexose monophosphate content of the muscle is due to epinephrin, and results from the breakdown of muscle glycogen. The usual observation of phosphate changes in both blood and muscle after the adm. of either insulin or epinephrin to the intact normal animal, is due to the reflex evocation of the secretion of one gland by the effects of the hormone of the other gland. The action of insulin esterifying blood inorganic phosphate, is considered in relation to the general action of insulin on carbohydrate metabolism.