Locked Nucleic Acid: Properties and Therapeutic Aspects
- 22 April 2008
- book chapter
- Published by Royal Society of Chemistry (RSC)
Abstract
In 1978 Zamecnik and Stephenson1 showed for the first time that messenger RNA (mRNA) repression could be achieved by single-stranded oligonucleotides (ONs). This mechanistic approach for gene inhibition was later called the antisense (AS) principle. The simplicity of this new principle captivated ma...Keywords
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