Electrolyte Redistribution in Cystic Fibrosis Fibroblasts Studied by Electron Probe Xray Microanalysis
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Ultrastructural Pathology
- Vol. 2 (1), 53-58
- https://doi.org/10.3109/01913128109031503
Abstract
The elemental composition of fibroblasts from cystic fibrosis (CF) patients and from healthy controls was compared by means of electron probe Xray micro-analysis. Significantly lower sodium levels (p < .01) and higher calcium levels (p < .02) were found in CF fibroblasts, indicating a disturbance of ion regulation in these cells. Treatment with Staphylococcus aureus protein A and gammaglobulin (proteins that may influence the ciliotoxic CF factor) did not change the elemental composition of the fibroblasts.Keywords
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