Approaches to oligoribonucleotide synthesis via phosphotriester intermediates

Abstract

Methods are described for the synthesis of uridylyl-(3′→ 5′)-uridine and uridylyl-(3′→ 5′)-uridylyl-(3′→ 5′)-uridine, in good yields a phosphotriester approach has been adopted with the internucleotidic linkages protected by aryl protecting groups.