Anaphylactic hyposensitization of rat mast cells in vitro by antigen.
- 1 November 1974
- journal article
- Vol. 18 (3), 431-7
Abstract
Anaphylactic hyposensitization of rat mast cells in vitro was demonstrated by preincubating the cells with specific antigen in suboptimal concentrations. The reduction of the histamine release was more pronounced when the cells were pre-incubated with increasing concentrations of antigen than with the final concentration. The inhibition remained unchanged for more than 3 hr. Non-specific antigen did not influence the histamine release, whereas a 70% inhibition was demonstrated by specific antigen. In rats sensitized to two different antigens, preincubation with one of these inhibited the subsequent histamine release induced by either of the two antigens. The hyposensitization could not be ascribed to blocking antibodies.This publication has 7 references indexed in Scilit:
- Release of Histamine from Sensitized Rat Peritoneal Cells by Specific and Unspecific AntigensActa Pharmacologica et Toxicologica, 2009
- Identification of IgG-antibodies in subjects with hay fever before and after specific hyposensitizing treatment.1973
- Storage of 5‐Hydroxytryptamine in Rat Mast Cells. Evidence for an Ionic Binding to Carboxyl Groups in a Granule Heparin‐Protein ComplexActa Physiologica Scandinavica, 1972
- Loss and recovery of leukocyte sensitivity to antigenic histamine release during intensive injection therapy with allergen extractJournal of Allergy and Clinical Immunology, 1971
- Mode of Storage of Histamine in Mast CellsActa Physiologica Scandinavica, 1966
- STUDIES ON THE MECHANISMS OF HYPERSENSITIVITY PHENOMENAThe Journal of Experimental Medicine, 1964
- A METHOD FOR THE FLUOROMETRIC ASSAY OF HISTAMINE IN TISSUES1959