Neuropathology of vigabatrin.
Open Access
- 1 February 1989
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 27 (S1), 43S-45S
- https://doi.org/10.1111/j.1365-2125.1989.tb03460.x
Abstract
1. Neuropathological changes in experimental animals have been observed with vigabatrin treatment in mice, rats and dogs. 2. These changes have comprised intramyelinic oedema which is reversible on cessation of treatment. 3. In human studies so far, no intramyelinic oedema has been noted. It is not clear whether humans will show the neurotoxicity observed in animals; close monitoring of patients is indicated.Keywords
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