A number of reports1, 2, 3 have indicated that terramycin is efficient in the treatment of colonic amebiasis. Although some instances of active diarrhea and dysentery were included in these reports, most of the patients described had low grade colonic infections and were in the nondysenteric stage. For this reason the authors are reporting their experiences with this drug in the treatment of 16 patients with active diarrhea or dysentery. Six of these patients (table 1, patients 1 through 6) were observed by one of us (W. A. S.) in the Tulane University of Louisiana at New Orleans. The 10