Studies on the Hepatocyte Protective Activity and the Structure-Activity Relationships of Quinic Acid and Caffeic Acid Derivatives from the Flower Buds of Lonicera bournei

Abstract

13 quinic acid derivatives along with caffeic acid, methyl caffeate, myo-inositol, bis[5-formylfurfuryl] ether and 6,7-dihydroxycoumarin were isolated from the ethanol extract of the flower buds of Lonicera bournei Hemsl., among which 8 compounds were firstly obtained from this genus. The effects of different solvent soluble fractions of the ethanol extract and the pure compounds on heptocyte death induced by D-galactosamine (D-GalN)/tumor necrosis factor α (TNF-α) were studied, and the structure-activity relationships were also discussed.