Interleukin 1 regulates human metallothionein gene expression.
Open Access
- 1 October 1985
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 5 (10), 2866-2869
- https://doi.org/10.1128/mcb.5.10.2866
Abstract
Incubation of cultured human cells with interleukin 1 leads to increased expression of the human metallothionein-IIA gene. Recently, metallothionein has been shown to be an efficient free radical scavenger, and induction by interleukin 1 may be part of a protective response to minimize damage by hydroxyl radicals.Keywords
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