ADRIAMYCIN AND DAUNOMYCIN GENERATE REACTIVE OXYGEN COMPOUNDS IN ERYTHROCYTES
- 1 January 1978
- journal article
- research article
- Vol. 52 (5), 878-885
Abstract
Adriamycin and daunomycin produced dose-related cardiac toxicity that may have been related to oxygen radicals. Addition of these compounds to human erythrocyte suspensions resulted in stimulation of hexose monophosphate shunt activity that was markedly impaired in the absence of HbO2. Evidence for generation of hydrogen peroxide by these compounds was provided by oxidation of reduced glutathione, by 14C-formate oxidation and by the catalase-aminotriazole trapping technique. Adriamycin and daunomycin apparently interact with HbO2 to generate reactive O2 metabolites. A similar interaction with oxymyoglobin may occur in the heart and produce oxygen radicals that injure cardiac myocytes.This publication has 11 references indexed in Scilit:
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