Transient Supersensitivity in the Partially Denervated Urinary Bladder of the Rat
- 1 October 1978
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 43 (4), 318-322
- https://doi.org/10.1111/j.1600-0773.1978.tb02272.x
Abstract
When examined 6-7 days after the unilateral removal of the pelvic ganglion, the detrusor muscle of the rat was sensitized to methacholine and noradrenaline [norepinephrine]. The threshold doses were lower while the intravesical pressure responses to doses above threshold were increased. Bladders examined 25-30 days after the partial denervation lacked signs of sensitization. It is suggested that the contralateral nervous pathway is responsible for the rapid disappearance of the supersensitivity.Keywords
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