The enhanced production of hyaluronic acid by cultured rat fibroblast cells treated with cyclic AMP and its dibutyryl derivative
- 4 February 1976
- journal article
- research article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 87 (2), 189-197
- https://doi.org/10.1002/jcp.1040870207
Abstract
Cells of a newly established rat fibroblast line (SEN) in culture synthesize mucopolysaccharides, which have been identified as hyaluronic acid, chondroitin‐4‐sulfate and heparan sulfate. Treatment of the cells with adenosine 3′:5′‐cyclic monophosphate resulted in a marked stimulation of production of hyaluronic acid, but not of the other mucopolysaccharides. Treated cells also showed increased activity of hyaluronic acid synthetase, a reduction in growth rate, and morphological alteration. In addition, 5‐bromodeoxyuridine was found to counteract greatly the cyclic AMP effect.This publication has 28 references indexed in Scilit:
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