The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase
- 11 March 2007
- journal article
- research article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 14 (4), 344-346
- https://doi.org/10.1038/nsmb1217
Abstract
Histone H3 Lys4 (H3K4) is methylated by yeast Set1–COMPASS and its mammalian homolog, the MLL complex. Human JARID1d can demethylate trimethyl-H3K4 (H3K4me3). We identified Drosophila melanogaster little imaginal discs (Lid) as the JARID1d homolog. We report that Lid knockdown using RNA interference results in a specific genome-wide increase in H3K4me3 levels without affecting other patterns of H3 methylation, and results in an altered distribution of the chromo-helicase protein Chd1.Keywords
This publication has 18 references indexed in Scilit:
- Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitmentMolecular Genetics and Genomics, 2006
- Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexesNature Structural & Molecular Biology, 2006
- Histone Demethylation by Hydroxylation: Chemistry in ActionACS Chemical Biology, 2006
- Double chromodomains cooperate to recognize the methylated histone H3 tailNature, 2005
- Molecular Regulation of Histone H3 Trimethylation by COMPASS and the Regulation of Gene ExpressionMolecular Cell, 2005
- An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylationNature, 2005
- Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1Cell, 2004
- Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1Nature, 2002
- COMPASS, a Histone H3 (Lysine 4) Methyltransferase Required for Telomeric Silencing of Gene ExpressionJournal of Biological Chemistry, 2002
- COMPASS: A complex of proteins associated with a trithorax-related SET domain proteinProceedings of the National Academy of Sciences, 2001