Delayed, relapsing experimental allergic encephalomyelitis in mice.
- 1 March 1981
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 126 (3), 819-822
- https://doi.org/10.4049/jimmunol.126.3.819
Abstract
Immunization of female SJL mice with an emulsion of lyophilized mouse spinal cord, pertussis vaccine, and complete Freund's adjuvant produces a delayed and often relapsing form of experimental allergic encephalomyelitis (DR-EAE). The mice develop initial signs of disease an average of 6 mo after immunization. Relapses occurred 2 wk to 11 mo after the initial illness. Some animals had multiple relapses. Pathologic examination of the brain and spinal cord revealed perivascular infiltration of mononuclear cells with acute demyelination. Areas of subacute and chronic demyelination ("plaques") were also seen. This model produces a clinical course of relapsing-remitting disease with pathologic evidence of both recent and old inflammatory lesions at various levels of the central nervous system. It thus more closely resembles multiple sclerosis than acute EAE.This publication has 6 references indexed in Scilit:
- Chronic Relapsing Experimental Allergic EncephalomyelitisArchives of Neurology, 1979
- Chronic relapsing experimental allergic encephalomyelitis: Effect of age at the time of sensitization on clinical course and pathologyActa Neuropathologica, 1979
- Chronic experimental allergic encephalomyelitis in rhesus monkeys and its modification by treatmentJournal of the Neurological Sciences, 1978
- CHRONIC DISSEMINATED ALLERGIC ENCEPHALOMYELITIS IN GUINEA PIGS*Annals of the New York Academy of Sciences, 1965
- A HISTOLOGIC STUDY OF EARLY LESION IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN GUINEA PIG AND RABBIT1962
- CHRONIC EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN MONKEYSJournal of Neuropathology and Experimental Neurology, 1948