Corticosteroid Production in vitro by the Interrenal Tissue of Killifish, Fundulus heteroclitus (Linn).

Abstract

Interrenal tissues of killifish were incubated in vitro with progesterone-16-H3. The interrenal tissue was found to have produced small amounts of radioactive compounds with chromatographic mobilities similar to cortisol, cortisone, and aldosterone. Cortisol was the major compound produced. These results would appear to be direct proof that the interrenal tissue is adrenocortical tissue and possesses the enzymes to convert progesterone to cortisol, cortisone, and aldosterone.