PRODUCTION OF ESTROGENIC HORMONE BY A TRANSPLANTABLE OVARIAN CARCINOMA

Abstract

A spontaneous ovarian carcinoma was found in a multiparous [female]] mouse. Several transplant generations were made into both normal and castrate [male][male] and [female][female] of the same strain. In [female][female] and spayed [female][female] constant oestrous obtains soon after a transplant is made. In [male][male] a good estrogenic response is obtained on the mammary glands. The tumor does not grow-in all inoculated animals, and in some few cases growth does not bring about a constant oestrous condition in [female][female]22.