Gaucher's disease is a rare, congenital, familial, constitutional disorder, possibly of lipoid metabolism, in which complex lipoids fail of complete disintegration and are stored in the reticulum cells of the lymphatic-hematopoietic system. The well known clinical manifestations are great enlargement of the spleen, enlargement of the liver, brownish pigmentation of the exposed parts of the skin, wedge-shaped thickenings of the conjunctiva near the cornea, marked hemorrhagic tendency, and characteristic blood changes, especially leukopenia and thrombocytopenia. Not only is the disease a familial one but the disposition to gross skeletal changes may also be familial, as has been shown by Ludwig Pick.1The interest in Gaucher's disease has recently been revived by the description of this gross osseous form of the disease; by finding additional aids to making the clinical diagnosis; by the determination of the chemistry of the so-called Gaucher substance, and by the defining of the relation of