Denosumab Treatment of Prostate Cancer With Bone Metastases and Increased Urine N-Telopeptide Levels After Therapy With Intravenous Bisphosphonates: Results of a Randomized Phase II Trial

Abstract

Prostate cancer was diagnosed in more than a half-million men worldwide in 2002 and was the cause of death for more than a quarter-million men.¹ x 1 World Health Organization. Health statistics and health information systems: Revised Global Burden of Disease (GBD) 2002 estimates. http://www.who.int/healthinfo/bodgbd2002revised/en/index.html. (Accessed May 15, 2008) Google Scholar See all References In up to 75% of patients with advanced disease prostate cancer metastasizes to bone, which may result in skeletal complications including pathological skeletal fractures, spinal cord compression, or radiation therapy or surgery to bone, collectively known as skeletal related events.² x 2 Coleman, R.E. Skeletal complications of malignancy. Cancer. 1997; 80: 1588 Crossref | PubMed | Google Scholar See all References