A 57-year-old woman had a chromophobe adenoma of the pituitary resulting in Cushing''s syndrome. Subtotal hypophysectomy improved her condition initially, but she died 4 years later. She had complained of a marked bilatera temporal visual defect and her visual acuity was reduced. Glycosuria was occasionaly present, ketosis was not observed, the 17-ketosteroid excretion was elevated and the adrenal glands were hypertrophied. The findings of 18 other cases reported in the literature are discussed and evaluated.