A COMPARISON OF THE EFFECTS OFIN VIVOANDIN VITROTHYROID HORMONES UPON THE OXYGEN CONSUMPTION OF RAT KIDNEY SLICES1
- 1 June 1959
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 64 (6), 937-941
- https://doi.org/10.1210/endo-64-6-937
Abstract
Immediately after removal of one kidney from thyroidectomized rats a large amount of thyroxine or triiodothyronine was injected intravenously. Slices made from the remaining kidney, removed 10 minutes later, had QO2 levels significantly higher than control values after storage at 4[degree]C for 48 hours in alanine buffer. After the injection of labeled thyroxine the I131 content of the injected kidney corresponded to .03 ug. thyroxine per mg. wet weight. Diiodotyrosine, injected under similar conditions, did not affect the QO2- Thyroxine added to slices from both control and injected kidneys was also effective in preserving QO2.Keywords
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