Neue Stoffe mit starker Wirkung auf die Vesikulardrüsen der kastrierten männlichen Maus. 9. Mitteilung über Sexualhormone und verwandte Stoffe.

Abstract

Even crystalline preparations of follicular hormone from mare''s urine contain an unknown precursor which can be converted by hydrogenation to a product which causes marked growth of the seminal vesicles. Preparations with 1 mouse unit in 2O[gamma] but inactive in the comb test can be obtained, an activity 5 times that of testosterone. From wool fat and from extracts of cinchona bark fractions can be obtained with 1 mouse unit in 100-20O[gamma] without hydrogenation, and with no action in the comb test. While the previously described [male] hormones show a ratio of 1 capon unit to 100 mouse units, these new preparations have a ratio of 10:1 and therefore belong to a new group of hormones.