Genetic models of sex effect in unipolar affective illness
- 30 June 1981
- journal article
- research article
- Published by Wiley in Acta Psychiatrica Scandinavica
- Vol. 64 (1), 85-91
- https://doi.org/10.1111/j.1600-0447.1981.tb00762.x
Abstract
Family study data on unipolar affective illness are analyzed by mutliple threshold models of inheritance that incorporate sex effect. In these models males and females share a common genetic-environmental liability, but the less prevalent sex, i.e., males, has a higher genetic threshold for the disorder. Neither single major locus (SML) nor multifactorial-polygenic (MFP) transmission can account for the sex differences in the morbid risk for unipolar disorder. The implications for genetic research in affective disorders are discussed.Keywords
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