Binding of Actinomyces naeslundii to glycosphingolipids
- 1 February 1987
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 55 (2), 487-489
- https://doi.org/10.1128/iai.55.2.487-489.1987
Abstract
The type 2 fimbrial lectin of Actinomyces naeslundii WVU45 mediated the binding of this bacterium to glycosphingolipids chromatographed on thin-layer silica gel plates. Radioiodinated bacteria attached to GM1, GD1b, and globoside. After chromatograms were treated with sialidase, the bacteria also bound to GD1a and GT1b. The actinomyces lectin apparently recognized the Gal.beta.3GalNAc termini of these gangliosides and the GalNAc.beta.3Gal terminus of globoside, suggesting that glycolipids containing these sequences may serve as receptors for A. naeslundii on mammalian cells.This publication has 11 references indexed in Scilit:
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- GANGLIOSIDES1964