Phantom studies simulating the impact of trabecular structure on marrow relaxation time, T2′
- 1 April 1994
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 31 (4), 380-387
- https://doi.org/10.1002/mrm.1910310406
Abstract
Phantom studies were conducted to investigate the impact of trabecular structure on the T2′ signal measured by MRI. For a separation of density from structural effects, several phantoms were built. They consisted of parallel polyethylene strings arranged in a variety of different patterns to simulate (a) a constant uniform trabecular distribution with increasing trabecular thickness and (b) different structures with identical overall trabecular density. An asymmetric spin echo sequence was used to determine the apparent relaxation time T2′. Changes in T2′ are induced by susceptibility differences between the polyethylene strings simulating trabeculae and Gd‐TPA doped saline simulating bone marrow. The results showed an increasing T2′ decay rate with (a) decreasing spacing while the string density was constant and (b) with increasing string density while the string arrangement was constant. The results demonstrate that the T2′ signal is affected not only by density but also by spatial distribution. However, the results also indicate that a separation of the two effects is not possible from a T2′ measurement alone, but that e.g., a matching CT slice that would provide purely density information is additionally needed. Theoretical simulations confirmed these results.Keywords
This publication has 19 references indexed in Scilit:
- Site-matched calcaneal measurements of broad-band ultrasound attenuation and single X-ray absorptiometry: Do they measure different skeletal properties?Journal of Bone and Mineral Research, 1992
- CT image analysis of the vertebral trabecular network in vivoCalcified Tissue International, 1992
- Quantitation of the susceptibility difference between trabecular bone and bone marrow: Experimental studiesMagnetic Resonance in Medicine, 1991
- Dependence of the velocity and attenuation of ultrasound in bone on the mineral contentPhysics in Medicine & Biology, 1991
- Trabecular structure: preliminary application of MR interferometry.Radiology, 1991
- Global and Regional Variations in the Spinal Trabecular Bone: Single and Dual Energy ExaminationsJournal of Clinical Endocrinology & Metabolism, 1991
- In vivo Quantitative characterization of trabecular bone by NMRMagnetic Resonance in Medicine, 1991
- Cancellous Bone StructureJournal of Computer Assisted Tomography, 1991
- Effect of trabecular bone on the appearance of marrow in gradient-echo imaging of the appendicular skeleton.Radiology, 1990
- The Effects of Bone on Proton NMR Relaxation Times of Surrounding LiquidsInvestigative Radiology, 1986