Cytoplasmic Budding of Human Lymphocytes Produced by Cortisone and Hydrocortisone in in vitro Preparations.

Abstract

Significant numbers of lymphocytes exhibiting cytoplasmic budding were found within 30 sec. following addition of cortisone or hydrocortisone to plasma and then to buffy coat of the blood of normal human subjects. It is suggested that cytoplasmic budding of lymphocytes may be a reversible process and that the occurrence of cytoplasmic budding, pycnosis or karyorrhexis may depend upon differential susceptibility of lymphocytes.