Serum gastrin concentrations were examined following atropinization in 30 patients with liver cirrhosis and in 30 control subjects either basally or after oral glycine load. Basal gastrinaemia and post-glycine serum increases above basal levels were found to be significantly greater in the cirrhotic group (48.56 ± 9.97 and 72.85 ± 10.88 pg/ml, respectively) than in the control group (32.36 ± 6.67 and 53.43 ± 9.67 pg/ml, respectively) (ρ < 0.001). Furthermore, the post-glycine serum gastrin rise appeared to be more prolonged in the cirrhotic group than in the control subjects. The serum gastrin changes in cirrhotics did not appear to be caused by gastric hypoacidity. There was no correlation in cirrhotic patients between the magnitude of the post-glycine serum gastrin rise and the severity of liver insufficiency.