Alkylation mutagenesis in Saccharomyces cerevisiae: lack of evidence for an adaptive response
- 1 May 1986
- journal article
- research article
- Published by Springer Nature in Current Genetics
- Vol. 10 (9), 647-655
- https://doi.org/10.1007/bf00410912
Abstract
We have found no evidence for an adaptive response for either lethality or mutagenesis following treatment of Saccharomyces cerevisiae with N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). The rad6 and rad52 mutants of S. cerevisiae are highly defective in MNNG and ethyl methanesulfonate induced mutagenesis of both stationary and exponential phase cells. These and other observations indicate that the mechanisms of repair of alkylation damage and mutagenesis differ markedly between S. cerevisiae and Escherichia coli.This publication has 36 references indexed in Scilit:
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