Renin‐angiotensin system is an important factor in hormone refractory prostate cancer
- 15 February 2006
- journal article
- research article
- Published by Wiley in The Prostate
- Vol. 66 (8), 822-830
- https://doi.org/10.1002/pros.20407
Abstract
Background The aim of this study was to perform a comprehensive evaluation of the renin‐angiotensin system (RAS) in prostate cancer. Methods We investigated the expression of RAS components in prostate cancer cells treated with hormonal agents. Real‐time PCR data showed the expression of the AT1 receptor, angiotensin I converting enzyme (ACE), and angiotensin I/II (Ang‐I/II) precursor in all 87 prostate tissue samples. Results Expression of these genes in hormone refractory prostate cancer (HRPC) was significantly higher than that in normal prostate tissue and untreated prostate cancer tissue. Western blot showed that protein expression of the AT1 receptor and Ang‐I/II was enhanced in LNCaP cells cultivated in steroid‐free medium. When LNCaP cells were stimulated with dihydrotestosterone (DHT), estradiol (E2), dexamethasone (DEX), or anti‐androgen drugs, protein expression of the AT1 receptor and Ang‐I/II was augmented. Conclusions The present data suggest that prostatic RAS is overexpressed in HRPC tissue, and expression of its components is influenced by several kinds of hormonal stimulation. ProstateKeywords
This publication has 45 references indexed in Scilit:
- Structural basis for antagonism and resistance of bicalutamide in prostate cancerProceedings of the National Academy of Sciences, 2005
- Neuroserpin (PI‐12) is upregulated in high‐grade prostate cancer and is associated with survivalInternational Journal of Cancer, 2005
- Cancer Statistics, 2003CA: A Cancer Journal for Clinicians, 2003
- Transactivation of ErbB1 and ErbB2 receptors by angiotensin II in normal human prostate stromal cellsThe Prostate, 2002
- Evidence for activation of the renin–angiotensin system in the human prostate: increased angiotensin II and reduced AT1 receptor expression in benign prostatic hyperplasiaThe Journal of Pathology, 2001
- Localization of angiotensin‐converting enzyme in the human prostate: pathological expression in benign prostatic hyperplasiaThe Journal of Pathology, 2001
- Angiotensin II enhances noradrenaline release from sympathetic nerves of the rat prostate via a novel angiotensin receptor: implications for the pathophysiology of benign prostatic hyperplasiaJournal of Endocrinology, 2001
- Identification, Distribution, and Expression of Angiotensin II Receptors in the Normal Human Prostate and Benign Prostatic HyperplasiaEndocrinology, 2001
- Regulation of cell proliferation and growth by angiotensin IIProgress in Growth Factor Research, 1994
- Androgen-dependent angiotensinogen and renin messenger RNA expression in hypertensive rats.Hypertension, 1992