Structural Insights Into the Signal Recognition Particle
- 1 June 2004
- journal article
- review article
- Published by Annual Reviews in Annual Review of Biochemistry
- Vol. 73 (1), 539-557
- https://doi.org/10.1146/annurev.biochem.73.011303.074048
Abstract
The signal recognition particle (SRP) directs integral membrane and secretory proteins to the cellular protein translocation machinery during translation. The SRP is an evolutionarily conserved RNA-protein complex whose activities are regulated by GTP hydrolysis. Recent structural investigations of SRP functional domains and interactions provide new insights into the mechanisms of SRP activity in all cells, leading toward a comprehensive understanding of protein trafficking by this elegant pathway.Keywords
This publication has 94 references indexed in Scilit:
- Heterodimeric GTPase Core of the SRP Targeting ComplexScience, 2004
- Signal Recognition Particle Binds to Ribosome-bound Signal Sequences with Fluorescence-detected Subnanomolar Affinity That Does Not Diminish as the Nascent Chain LengthensJournal of Biological Chemistry, 2003
- Induced structural changes of 7SL RNA during the assembly of human signal recognition particleNature Structural & Molecular Biology, 2002
- Distinct Modes of Signal Recognition Particle Interaction with the RibosomeScience, 2002
- Crystal Structure of SRP19 in Complex with the S Domain of SRP RNA and Its Implication for the Assembly of the Signal Recognition ParticleMolecular Cell, 2002
- Conformational change of the N-domain on formation of the complex between the GTPase domains of Thermus aquaticus Ffh and FtsYBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 2002
- Structural and energetic analysis of RNA recognition by a universally conserved protein from the signal recognition particleJournal of Molecular Biology, 2001
- Crystal Structure of the Conserved Subdomain of Human Protein SRP54M at 2.1Å Resolution: Evidence for the Mechanism of Signal Peptide BindingJournal of Molecular Biology, 1999
- Regulation by the ribosome of the GTPase of the signal-recognition particle during protein targetingNature, 1996
- GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocationNature, 1993