Effect of Changing Potassium Ion Concentrations on Rat Cerebral Slices In Vitro: A Study During Development
- 30 April 1981
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 36 (5), 1853-1857
- https://doi.org/10.1111/j.1471-4159.1981.tb00440.x
Abstract
Adult rat cerebral cortex slices when incubated in media of increasing K+ concentrations, from 3-20 mM (physiological conditions), exhibited an increase of Ki+ and a decrease of Nai+ and Cli-. This phenomenon appeared at 30 days postnatally, which is fairly late during development. Over 20 mM-K+ (pathological conditions) an intense water uptake was observed together with an increase of Nai- and Cli-. This was observed in both adult and young animals. The results are discussed in relation to the well known properties of glial (Nai-, K+)-ATPase and carbonic anhydrase.Keywords
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