(S)-(2-(2‘-Pyridyl)ethyl)cysteamine and (S)-(2-(2‘-Pyridyl)ethyl)-d,l-homocysteine as Ligands for the “fac-[M(CO)3]+” (M = Re, 99mTc) Core
- 17 May 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Inorganic Chemistry
- Vol. 44 (12), 4118-4120
- https://doi.org/10.1021/ic050254r
Abstract
The reaction of fac-[NEt4]2[Re(CO)3Br3] with (S)-(2-(2‘-pyridyl)ethyl)cysteamine, L 1, in methanol leads to the formation of the cationic fac-[Re(CO)3(NSN)][Br] complex, 1, with coordination of the nitrogen of the pyridine, the sulfur of the thioether, and the nitrogen of the primary amine. When fac-[NEt4]2[Re(CO)3Br3] reacts with the homocysteine derivative (S)-(2-(2‘-pyridyl)ethyl)-d,l-homocysteine, L 2, the neutral fac-Re(CO)3(NSO) complex, 2, is produced with coordination of the nitrogen of the primary amine, the sulfur of the thioether, and the oxygen of the carboxylate group, while the pyridine ring remains uncoordinated. The analogous technetium-99m complexes, 1‘ and 2‘, were also prepared quantitatively by the reaction of L 1 and L 2 with the fac-[99mTc(CO)3(H2O)3]+ precursor at 70 °C in water. Given that both (S)-(2-(2‘-pyridyl)ethyl)cysteamine and homocysteine can be easily N- or S-derivatized by a bioactive molecule of interest, both the NSN or NSO ligand systems could be used to develop target-specific radiopharmaceuticals for diagnosis and therapy.Keywords
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