Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome
Open Access
- 28 May 2008
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 22 (9), 3224-3233
- https://doi.org/10.1096/fj.07-104539
Abstract
Adults with Down syndrome (DS) develop Alzheimer neurofibrillary degeneration in the brain, but the underlying molecular mechanism is unknown. Here, we report that the presence of an extra copy of th...Keywords
Funding Information
- National Institutes of Health (AG027429, HD043960, HD038295, AG019158)
- Alzheimer's Association (IIRG-05-13095)
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