Respiratory Failure Associated with Familial Depression of Ventilatory Response to Hypoxia and Hypercapnia
- 14 October 1976
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 295 (16), 861-865
- https://doi.org/10.1056/nejm197610142951604
Abstract
Respiratory failure has been associated with depressed ventilatory responses to hypoxia or hypercapnia or both. The possibility that familial factors are responsible for decreased chemosensitivity prompted this study of a child with unexplained respiratory failure and normal lung function. We found his ventilatory response to hypoxia and hypercapnia to be virtually absent. Studies of six healthy immediate family members (parents and siblings) showed that hypoxic response, as measured by an index of the relation between ventilation and hypoxia (index A), was consistently reduced: 45±8.7 S.E.M. (normal, 127±8.7)(P<0.005). Response to hypercapnia, measured as the slope of the ventilatory response to hypercapnia, was lower than normal, averaging 0.95±0.16 liters per minute per millimeter of mercury (normal, 1.76±0.13)(P<0.01).This publication has 27 references indexed in Scilit:
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