Suppression of Tuberculin and Phytohemagglutinin Skin Tests by Large Tumors in Inbred Mice

Abstract

Suppression of PPHA and PPD paw test was observed in mice with a transplantable methylcholanthrene-induced sarcoma. Serum from tumor-bearing mice contained a factor which suppressed paw test reactivity in normal mice. Less suppression of paw test was seen in mice previously injected with complete Freund adjuvant. It is suggested that these observations form the basis of an experimental model for study of tumor-associated cutaneous anergy.